Endocrine Abstracts

Introduction: The association between autoimmune thyroid disease and thyroid cancer is a dynamic field regarding the prevalence data and the common pathogenic background.Aim: We report a sixth decade women case with a 1 year history of Graves’ disease that was discovered with an aggressive differentiated thyroid carcinoma.Case report: M.E. 56-year-old female has a 10 months history of daily medium dose of thyamazolum which was...

Introduction: Metastases in pituitary gland are extremely rare with a reported prevalence of 1% among all pituitary tumor resections and 1 to 3.6% among post-mortem studies (1). Breast and lung cancer are the most common sites of primary tumor that have been reported to metastasize in pituitary gland and about 7% of all metastases are symptomatic (2.3).Case report: A 62-year-old male with a 40-pack-year smoking history and no previous medical conditions ...

Cushing’s disease is relatively rare and affects most commonly adults aged 20 to 40. It is associated with high morbidity and mortality; early detection and diagnosis of Cushing’s disease may lead to decreased this two facts and improved quality of life.We present a 32-year-old man with abdominal purple striae, central obesity with typical ‘moon face’ and oscillatory blood pressure values.Hormonal exams revealed...

Introduction: Testosterone therapy in elderly is controversial, because of the effect on prostate. The old age itself is not a contraindication in the therapy of hypogonadism.Aim: We analyze the effect of 24 months of therapy with testosterone undecanoat depot (1000 mg/4 ml) (TUD) on the volume of the prostate (VP).Patients and method: The patients were 79 symptomatic hypogonadic men, with normal value of PSA (<4 g/l). The urol...

Introduction: Sorafenib, an orphan medication, is an oral protein kinase inhibitor, used in the treatment of hepatic, advanced renal and breast cancer, or metastatic iodine-refractary thyroid cancer. The drug also inhibits angiogenesis, and VEGF, having a dual effect on the tumor cells as well as on the tumor vasculature.Aim: We present a case with hyperthyroidism, as adverse effect of the therapy with sorafenib, but with no markers of thyroid autoimmuni...

Hypovitaminosis D is frequent in population over 65 years age, producing a secondary hyperparathyroidism, increase the bone remodeling, bone loss and osteoporotic fractures, loss of the muscle force.Daily dose of 0.5 μg alfacalcidol was effectively in improved muscle strength in elderly and reduced falls. The bisphosphonates have been shown to increase Bone Mineral Density (BMD) and reduce bone turnover in postmenopausal osteoporosis. The combined a...

Background: Pituitary insufficiency is an uncommon endocrine disorder (incidence 2–4 per 100 000 per year), which clinical symptoms depend on the degree of hormone depletion and the rapidity of onset.Aim: To determine the clinical presentation, aetiology and clinical forms in 150 patients diagnosed with pituitary insufficiency.Material and methods: Retrospective study of clinical records of 150 patients with pituitary insuffic...

Background: Erectile dysfunction (ED) is an increasingly recognized condition among HIV-infected, however its prevalence and etiology remain unclear. Our aim was to asses prevalence and risk factors associated to ED in this population.Methods: A cross-sectional study was performed, 88 male HIV-positive without hepatitis C or diabetes were studied. Patients were classified according antiretroviral treatment (ART): naïve, protease inhibitor (PI)-conta...

Tuberculous thyroiditis is a very rare disease. Its clinical features are non-specific in most of the cases, mimicking other thyroid diseases. Confusions most frequently made are those with thyroid cancer and toxic nodular goiter. Therefore, diagnosis often comes as a histopathological surprise, after thyroid ablation for other reasons.Thyroid tuberculosis was diagnosed histopathologically in six out of 1232 cases of thyroid surgery. Preoperatory diagnos...

Background : The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is of an unprecedented scale, with an ever-growing impact on healthcare systems. The clinical presentation of coronavirus disease 2019 (COVID-19) is diverse, ranging from asymptomatic illness to respiratory failure requiring admission to the intensive care unit (ICU). Risk factors for severe presentation include old age, male gender, underlying comorbidities such as metabolic syndr...